Polidori was not originally an author. He was a physician, and a young one at that, earning his degree from the University of Edinburgh at the age of 19. Being an attractive prodigy, he caught the eye of the poet, Lord Byron, who hired him on as his personal physician and took him to Europe.
Byron was by then very famous throughout the continent, and the scandal of his divorce and speculation about his sexuality was rampant. Publisher John Murray offered Polidori 500 pounds to keep a journal of his travels with the poet. This journal became a source of contention between Polidori and Byron, who was on the one hand flattered by the attention and on the other annoyed and angered by the intrusion into his privacy. There has been speculation that Polidori and Byron became romantically entangled. Certainly, Polidori was fascinated with the famous poet, but whether the feeling was mutual is debatable.

Byron and Polidori quarrelled, partly because Byron felt Polidori had puffed up airs, delusions about becoming a famous author, and was not content with doing the job which he had been hired to do. He found Polidori's personality irritating, and Byron's journal is full of dismissive and acerbic references to Polidori's shortcomings. Byron also feared that Polidori's journal would expose too many of his secrets. Thus, Polidori was dismissed from his position. Devastated, he traveled through Italy and then returned to England, where his book was published two years later.

Ruthven, the vampyre, is seductive and deadly. He is strong, masculine, handsome, and sneering at those he feels are beneath him. Readers today will recognize the basis for the English literary vampires which followed, including Dracula. Ruthven is a romantic, alluring, and devastating character who cuts a swath through a room full of women like a hot knife through butter.
On the other hand, the other main character, Aubrey, who finds himself drawn to Ruthven and who observes the terrible effects of being close to him, is meant to be a sympathetic character and most scholars agree that Polidori identified that character as being like himself. There is a clear (at least in my mind as a reader) homosexual subtext to the work, and Aubrey is drawn to Ruthven and seems most angered at the fact that Ruthven chooses young women as his victims rather than noticing him as a potential suitor. Aubrey comes off to me as a sad and bitter man who wishes he were smart enough, handsome enough, strong enough and who fails miserably. In the end, that is the impression which Polidori himself makes as well.
In trying to ruin Byron's reputation, Polidori only added to his fame. The novella was made into a French play the very next year and later into two operas.
As for Polidori himself, he committed suicide in 1821, leaving behind a string of gambling debts. His sister Charlotte transcribed his diary, omitting anything that might embarrass her family (which likely included anything relating to a possible relationship with Byron), and then she destroyed the original.
Whatever you might feel about the author himself, the book itself is a classic. The character of Ruthven is an archetype and serves as a model for all vampire authors who have followed.
The Vampyre is available as a free e-book through Project Gutenberg (http://www.gutenberg.org/ebooks/6087).
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